Endocrine Abstracts

Introduction: The Food and Drug Administration (FDA) had issued warnings on the increased risk of diabetic ketoacidosis and Fournier’s gangrene with patients using Sodium-glucose cotransporter-2 (SGLT-2) inhibitors. Herein, we report a case of simultaneous Fournier’s gangrene and diabetic ketoacidosis after initiation of treatment with Empagliflozin.Case Presentation: We report a case of a 54-year-old woman with type 2 diabetes on empagliflozin...

Background: Hypocalcaemia post parathyroidectomy and thyroidectomy is common and usually transient. A variety of drugs including tyrosine kinase inhibitors can cause hypocalcaemia. We present a case where a patient with primary hyperparathyroidism on imatinib with pre-op calcium 2.86 mmol/l, post-operatively developed resistant hypocalcaemia necessitating prolong hospitalisation and multiple calcium infusions which was not solely attributable to hungry bone syndrome.<p cla...

Introduction: NF1 or Von-Recklinghausen’s disease, an autosomal dominant neuro-cutaneous disorder results from NF1 (a tumour-suppressor gene) mutation, predisposing to neoplasms mainly affecting eye, skin and nervous system but rarely pheochromocytoma (0.1-5.7%). The incidence increases to 20-50% if NF1 is associated with hypertension.Case history: 30 years female, known NF1 since 2005 and multiple laparotomies for intra-abdominal neurofibromas pres...

Introduction: Denosumab, a human monoclonal antibody used in osteoporosis and second line treatment option for hypercalcaemia, can cause profound hypocalcaemia especially in Vitamin-D depleted and cancer patients.Case history: 56 years female, with diabetes, hypertension on metformin, empagliflozin, amlodipine and ramipril, presented with 3 months history of backache, no red flag signs, clinically and hemodynamically stable except mild confusion and spin...